Endocrine Abstracts

3beta-hydroxysteroid dehydrogenase (3beta-HSD) expression is essential for the synthesis of all classes of steroid hormones, converting delta5-3beta-hydroxysteroids into hormonally active delta4-3-ketosteroids in NAD+-dependent reactions. A variety of 3beta-HSD isoforms have been described in primate, rodent and other mammals, often exhibiting distinct kinetic properties, preferential subcellular localization, as well as alternative substrate s...